NMN 是 NAD⁺ 的重要前驅物之一。近年來，多項國際人體臨床試驗針對 NMN 的安全性、耐受性與 NAD⁺ 提升效果進行系統性評估。整體而言，NMN 在既定劑量範圍內，於健康成人中普遍具有良好的安全性與耐受性，並可提升體內 NAD⁺ 水準。
NMN 人體臨床試驗關鍵年表（2016–2024）
近年 NMN 已從動物研究逐步進入人體臨床研究階段。從亞洲頂尖學府到歐美研究機構，多國多中心合作的隨機對照試驗指出，NMN 在既定劑量範圍內，普遍具有良好的安全性與耐受性，並能提升體內 NAD⁺ 水準；但在抗老化、疾病改善或長期效果方面，仍需更多大型人體研究進一步確認。以下整理具有里程碑意義的研究：
研究對象：10 名健康男性。研究主題：全球首個 NMN 人體臨床啟動研究，初步驗證安全性與體內代謝路徑，為後續所有 NMN 人體研究奠定基礎。
研究對象：10 名健康男性。研究主題：正式發表首份 NMN 人體安全性報告，確認單次口服 100–500 mg 在受試者中具良好耐受性，未觀察到明顯副作用。
研究對象：25 名更年期前後且具肥胖傾向的女性。研究主題：每日 250 mg 連續 10 週，研究顯示可顯著提升骨骼肌的胰島素敏感性，是 NMN 在代謝健康領域的重要里程碑。
研究對象：48 名業餘跑者。研究主題：NMN 結合規律訓練可提升骨骼肌氧氣利用效率（最大攝氧量 VO₂max），且呈劑量依賴性，每日 600–1,200 mg 效果較為明顯，是 NMN 與運動表現的代表性研究。
研究對象：65 歲以上男性。研究主題：聚焦健康老化指標。研究顯示 NMN 可改善老年族群的肌肉功能與步行速度，並在聽覺表現上呈現潛在助益。
研究對象：80 名中年健康成人。研究主題：大規模隨機雙盲、安慰劑對照試驗。每日 600–900 mg NMN 對提升血液 NAD⁺ 水平與 6 分鐘步行距離效果最為顯著，建立明確的劑量—生理反應關聯。
研究對象：各類特定族群。研究主題：多元應用探索。研究方向延伸至改善睡眠品質、緩解潰瘍性結腸炎，以及提升卵子品質（輔助生殖）等具體臨床主題，標誌 NMN 研究進入更廣泛的應用驗證階段。
整體研究結論
- 安全性：多項人體研究顯示，於既定劑量範圍內 NMN 具有良好耐受性。
- NAD⁺ 提升效果：多項雙盲對照試驗證實 NMN 補充可提升血液 NAD⁺ 濃度。
- 長期效益：仍需要更多大型、長期、嚴謹的人體研究來確認。
- 研究方向：正逐步擴展至代謝健康、免疫、運動表現等多元領域。
iHealth NMN 重視科學研究基礎、原料純度與品質管理，致力於提供符合國際標準的營養補充選擇，協助重視健康管理的消費者，從日常保養中支持身體正常機能。
NMN is one of the principal NAD⁺ precursors. In recent years, a series of international human clinical trials have systematically evaluated NMN's safety, tolerability, and ability to raise NAD⁺. Overall, within the dose ranges studied, NMN appears to be well tolerated in healthy adults and can raise circulating NAD⁺ levels.
Key milestones in NMN human clinical trials (2016–2024)
NMN research has gradually moved from animal studies into human clinical trials. From leading universities in Asia to research institutions in the United States and multi-national multi-centre collaborations, randomised controlled trials generally report that, within the defined dosage ranges, NMN is well tolerated in healthy adults and can raise NAD⁺ levels. Anti-aging effects, disease-related benefits, and long-term outcomes still require further large-scale human studies. Key milestone studies are summarised below:
Subjects: 10 healthy men. Focus: The world's first human clinical trial of NMN — preliminary evaluation of safety and metabolic pathways. This study laid the foundation for every NMN human trial that followed.
Subjects: 10 healthy men. Focus: The first formally published NMN human safety report, confirming that single oral doses of 100–500 mg were well tolerated with no notable adverse effects.
Subjects: 25 perimenopausal/postmenopausal women with obesity. Focus: 250 mg daily for 10 weeks significantly improved skeletal-muscle insulin sensitivity — a landmark study for NMN in metabolic-health research.
Subjects: 48 amateur runners. Focus: NMN combined with regular training improved skeletal-muscle oxygen utilisation (VO₂ max) in a dose-dependent manner, with 600–1,200 mg per day producing the strongest effect — a representative study of NMN and exercise performance.
Subjects: Men aged 65 and over. Focus: Healthy-aging indicators. NMN supplementation was reported to improve muscle function and gait speed in older adults, with potential benefits also observed for hearing performance.
Subjects: 80 middle-aged healthy adults. Focus: Large-scale randomised, double-blind, placebo-controlled trial. 600–900 mg NMN per day produced the most pronounced increases in blood NAD⁺ and 6-minute walk distance, establishing a clearer dose–response relationship.
Subjects: Various specific populations. Focus: Expanding into diverse applications — research directions extend to sleep-quality improvement, ulcerative colitis support, and oocyte quality in assisted reproduction, marking a broader clinical-application phase for NMN research.
Overall research conclusions
- Safety: within the dosage ranges studied, multiple human trials report good tolerability.
- NAD⁺ elevation: several double-blind controlled trials confirm that NMN can raise circulating NAD⁺ levels.
- Long-term benefits: larger, longer, and more rigorous human studies are still needed.
- Research direction: gradually expanding into metabolic health, immunity, exercise performance, and other areas.
iHealth NMN places strong emphasis on a scientific foundation, ingredient purity, and quality management — committed to providing supplement options that meet international standards and supporting normal everyday function for those who care about long-term health management.